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News Partnering Press Release

Nimble Therapeutics Announces Achievement of Development Milestones from Multiple Partnered Programs Connected to a Strategic Large Pharma Collaboration

MADISON, Wis.–Nimble Therapeutics Inc. today announced the company has achieved the first development milestone for each of several programs attached to a multi-target collaboration with an undisclosed large pharma partner.

Nimble will receive payments for each milestone connected to the collaboration, and the company remains eligible for additional future downstream milestones attached to each program as development continues.

“This is a significant accomplishment for our young company as we work with our partners to create important medicines for the benefit of patients, and we look forward to supporting this partner as they continue the development activities for each program.” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics.

“Delivering lead candidates to one of our first partners validates the power of our platform, approach, and team; and clearly demonstrates the value that Nimble brings to its partners. We are working diligently to deliver state of the art peptides for each and every partnered program and are confident that these efforts will result in additional milestones being earned by Nimble in 2022, and beyond.”

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble integrates the unrivaled chemical and structural diversity of its proprietary, light-directed, massively parallel solid-phase synthesis with biological display techniques, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics. For more information please see www.nimbletherapeutics.com.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20220517005323/en/Nimble-Therapeutics-Announces-Achievement-of-Development-Milestones-From-Multiple-Partnered-Programs-Connected-to-a-Strategic-Large-Pharma-Collaboration

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News Partnering Press Release

Nimble Therapeutics and Incyte Expand their Strategic Research Collaboration to Discover Additional Novel Peptide Therapeutics

Madison, WI, USA September 14, 2021 Nimble Therapeutics, a biotechnology company revolutionizing the discovery and development of peptide therapeutics, today announced their strategic research collaboration with Incyte (NASDAQ: INCY) has been expanded to include discovery of additional novel peptide therapies.

“Nimble looks forward to building upon on the already strong collaboration between the Nimble and Incyte scientific teams. The expansion of the collaboration serves as yet another important validation of Nimble’s powerful capabilities and approach towards engineering the next generation of peptide therapeutics”, said Jigar Patel, CEO and Founder of Nimble Therapeutics.

Under the terms of the agreement, Nimble will receive an upfront payment and reimbursement of certain research program costs and may become eligible for downstream milestone payments and royalties. Incyte has exclusive rights to develop and commercialize any peptides discovered under the collaboration and has an option to further expand the collaboration to include additional targets.

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics.

Connect with us on LinkedIn at www.linkedin.com/company/nimble-therapeutics or visit our website at www.nimbletherapeutics.com to learn more.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20210914005143/en/Nimble-Therapeutics-and-Incyte-Expand-their-Strategic-Research-Collaboration-to-Discover-Additional-Novel-Peptide-Therapeutics

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News Press Release

Nimble Therapeutics Appoints Cyrus Arman, PhD, MBA as Chief Business Officer

Madison, WI, USA September 08, 2021 — Nimble Therapeutics, an industry-leading peptide therapeutic discovery and optimization company, today announced the appointment of Dr. Cyrus Arman as Chief Business Officer. Cyrus will be responsible for structuring strategic alliances, licensing agreements, and financial investments, and will further provide management and strategic leadership to the organization. The appointment comes at a time of significant growth for Nimble Therapeutics, as the company continues to advance its technology platform and build out its strategic partnerships. His appointment represents the first step in Nimble’s expansion toward becoming a fully integrated biotechnology company.

Cyrus has over 12 years of experience in corporate, clinical, and commercial strategy. Most recently, he served as Vice President of Corporate Development and Strategy at NEUVOGEN, Inc, an immuno-oncology firm developing cancer vaccines. Prior to NEUVOGEN, Dr. Arman contributed to rebuilding and running Amgen’s Global Competitive Intelligence and Strategy unit, and later served as a Director in Amgen’s Corporate Strategy group.

“We’re excited to welcome Cyrus to our management team at Nimble,” said Jigar Patel, PhD, Founder and CEO of Nimble Therapeutics. “Cyrus brings valuable experience devising strategy, executing transactions, and leveraging innovation that will enable Nimble to deliver on the promise of peptide therapeutics.”

Cyrus has an MBA from the University of California Los Angeles, a PhD in Neuroscience and an MS in Biomedical Engineering from the University of Southern California, and a BS in Biopsychology from the University of California San Diego.

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics.

Connect with us on LinkedIn at www.linkedin.com/company/nimble-therapeutics or visit our website at www.nimbletherapeutics.com to learn more.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20210908005289/en/Nimble-Therapeutics-Appoints-Cyrus-Arman-PhD-MBA-as-Chief-Business-Officer

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News Partnering Press Release

Nimble Therapeutics and RayzeBio Announce Strategic Research Collaboration to Discover & Develop Novel Peptide-Based Radiopharmaceuticals

Madison, WI, USA, & San Diego, CA, USA June 28, 2021 — Nimble Therapeutics and RayzeBio today announced the companies have entered a strategic collaboration to discover and develop novel peptide-based radiopharmaceuticals for treatment of cancer.

“We are excited to welcome RayzeBio to our growing family of partners” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics. “Through our pioneering work, we have built a platform to rapidly identify drug-like hits and optimize them into leads, and conduct elaborate medicinal chemistry campaigns to engineer candidates with optimal potency, selectivity, stability, and other important attributes. This agreement with RayzeBio underscores the value inherent in Nimble’s platform to advancing the radiopharmaceutical field.”

“Nimble’s platform technology is promising,” said Ken Song, M.D., CEO of RayzeBio. “Nimble’s rational approach to using its platform to identify novel peptide-like molecules allows us to further expand our radiopharmaceutical pipeline and pursue multiple therapeutic programs in parallel.”

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment, research reimbursements and may also receive further milestone payments and royalties on sales of resulting products. RayzeBio has exclusive rights to develop and commercialize peptides discovered under the collaboration, and an option to further expand the collaboration to include additional targets.

About Nimble Therapeutics
Nimble Therapeutics is a biotechnology company revolutionizing the discovery & development of peptide therapeutics. The company’s discovery platform integrates leading-edge peptide synthesis, bioinformatic and chemoinformatic tools, a variety of naïve and scaffolded chemical libraries, custom screening and validation assays, and accelerated medicinal chemistry. The company has established partnerships with leading pharmaceutical and biotech companies, and seeks to leverage its technology across many therapeutic areas. For more information, please visit www.nimbletherapeutics.com.

About RayzeBio
RayzeBio is a biotechnology company focused on improving outcomes for people with cancer by harnessing the power of targeted radioisotopes. With a focus on clinically validated solid tumor targets, RayzeBio is developing novel peptide mimetic binders to deliver potent therapeutic radioisotopes such as Actinium-225, an alpha-emitter. The company is backed by a syndicate of sophisticated healthcare investors and was established in 2020. For additional information, please visit www.rayzebio.com.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, Ph.D.
Vice President, Corporate Development
info@nimbletherapeutics.com

RayzeBio, Inc.
Ken Song, M.D.
President and CEO
info@rayzebio.com

View the full press release here: https://www.businesswire.com/news/home/20210628005106/en/Nimble-Therapeutics-and-RayzeBio-Announce-Strategic-Research-Collaboration-to-Discover-Develop-Novel-Peptide-Based-Radiopharmaceuticals

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News

Biomarker Research by Nimble Scientists Featured in The Rheumatologist

Link: https://www.the-rheumatologist.org/article/researchers-propose-a-sensitive-specific-biomarker-for-rheumatoid-arthritis/?singlepage=1&theme=print-friendly

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News Partnering Press Release

Nimble Announces Strategic Research Collaboration with Incyte to Discover Novel Peptide-Based Therapeutics

Madison, WI, USA, Oct. 5, 2020 — Nimble Therapeutics Inc. today announced the company has entered into a strategic collaboration with Incyte (NASDAQ: INCY) to discover first-in-class peptide therapies across various disease areas.

“This is an important collaboration for both companies to discover novel peptide based therapeutics,” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics. “We are excited to partner with Incyte, an organization with world-class drug discovery, development and commercialization capabilities, to ensure maximal patient impact across multiple disease indications.”

The collaboration will leverage Nimble’s proprietary peptide synthesis, screening and optimization platform, coupled with its high chemical diversity and integrated suite of assays to enable faster discovery and optimization of promising compounds for intracellular and extracellular targets.

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment, reimbursement of certain research program costs and may become eligible for downstream milestone payments and royalties. Incyte has exclusive rights to develop and commercialize any peptides discovered under the collaboration, and an option to further expand the collaboration to include additional targets.

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News

Nimble Therapeutics spins out of Roche, saving Madison jobs

A new drug discovery and development company is taking root in Madison, and it will prevent more than a dozen skilled scientists here from losing their jobs.

Nimble Therapeutics formed in April, spun out of Roche Sequencing Solutions, originally NimbleGen Systems, which is slated to close by June 2020.

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News

Roche Spinout Nimble Therapeutics Bags $10M to Find New Peptide Drugs

For the past five years, Jigar Patel and a group of fellow Roche employees have been quietly developing drug discovery technology at the global pharma company’s outpost in Madison, WI. Now, they’re setting out on their own to see if their approach to identifying promising peptide-based therapies can have an impact on the sector.

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News Press Release

Nimble Therapeutics Spins Out from Roche to Commercialize Novel Drug Discovery Technology with Financing from Telegraph Hill Partners

April 30, 2019 (Madison, WI): Nimble Therapeutics has begun operating as a standalone business after spinning out from F. Hoffmann La Roche (SIX: RO, ROG; OTCQX: RHHBY) to commercialize its proprietary chemical synthesis technology for drug discovery and development. The company also completed a Series A financing led by Telegraph Hill Partners (San Francisco, CA).

Initially, Nimble Therapeutics will leverage the unparalleled speed and flexibility of its proprietary chemical synthesis platform, developed at Roche, to accelerate the discovery and optimization of macrocyclic peptidomimetics as novel therapeutics. “As a fully independent company, Nimble Therapeutics will establish strategic partnerships with pharmaceutical companies to jointly develop unique drug candidates more efficiently across many therapeutic areas”, notes Dr. Jigar Patel, who led the development of the technology and will serve as CEO of the company.

Nimble Therapeutics has hired the former Roche team that helped develop its chemical synthesis technology for drug discovery. The company’s platform, validated over many years and with over 20+ collaborations, provides the ability to synthesize millions of unique natural and modified peptide-based molecules simultaneously. These molecules can be efficiently screened and optimized through rapid iterations to identify novel entities with the desired characteristics using the Nimble platform.

As part of its growth strategy, the company will expand its current collaborations and strategically develop new relationships in key therapeutic areas. “The Roche team saw the value in separating the business to enable it to expand its platform and work on a variety of therapeutic areas with strategic partners”, said Dr. Deval Lashkari, Senior Partner at Telegraph Hill Partners and board director at Nimble Therapeutics, “Nimble’s capabilities are truly revolutionary and we are excited to work with the company in a shared vision to grow the business into a leading drug discovery partner for the pharmaceutical industry.”