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News Press Release

Nimble Therapeutics names Pete Gough as Chief Scientific Officer

Madison, WI, USA  November 30, 2022 — Nimble Therapeutics, an industry-leading peptide therapeutics company, today announced the appointment of Pete Gough, D. Phil. as Chief Scientific Officer (CSO). In this newly created role, Dr. Gough will spearhead the expansion of Nimble’s internal drug discovery capabilities that will enable further development of its own pipeline of proprietary therapeutics and drive Nimble towards becoming a fully integrated biotechnology company.

Dr. Gough has more than 25 years of experience in discovery research, both in academic settings as well as in the life sciences industry, and a track record of success in drug discovery and development, driving research programs into clinical study by building and leading high-performance teams. Prior to joining Nimble, Pete served as the CSO for Inzen Therapeutics, a Flagship company pioneering the newly discovered science of Thanokine Biology. At Inzen, he helped advance the company from seed stage to a successful Series B through the development of their pipeline of potentially transformational Immuno-Oncology therapeutics. Previously, Pete spent 15 years at GSK in roles of increasing responsibility. He served as Head of the Hepatitis B Virus Discovery Performance Unit (DPU) where he led GSK’s efforts to develop a functional cure for HBV including proof of concept studies for bepirovirsen. He also served as Head of the Host Defense DPU, and prior to that was Head of Biology and DMPK in the Pattern Recognition Receptor DPU. Pete led, and oversaw, the discovery and development of a number of clinical assets across multiple therapeutic areas including RIP1 kinase inhibitor GSK2982772 and STING agonist GSK3745417.

“We’re excited to welcome Pete to our management team at Nimble,” said Jigar Patel, PhD, Founder and CEO of Nimble Therapeutics. “Since our formation in 2019, Nimble has worked diligently to optimize and validate our peptide discovery platform. Pete brings invaluable experience in drug discovery and development across multiple therapeutic areas that will enable Nimble to deliver on the promise of peptide therapeutics through progressing and expanding our own internal pipeline.”

“Nimble has built the industry leading platform for discovering peptide therapeutics that solves for the challenges that everyone else in the field is struggling with,” said Dr. Gough. “I’m very excited to be part of the team and to help realize the truly transformative nature of the Nimble platform by advancing novel medicines into the clinic.”

Earlier in his career, Pete was a Research Assistant Professor in the Department of Pathology at the University of Washington. He received his D. Phil. and M. A. from the University of Oxford. Pete has authored/co-authored over 100 scientific papers in peer-reviewed journals and has been an invited speaker at numerous academic institutions and scientific conferences.

About Nimble Therapeutics

Nimble is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics. Nimble has extensively validated its platform to identify highly biologically active compounds for multiple programs, spanning a wide variety of therapeutic target classes.

Connect with us on LinkedIn at www.linkedin.com/company/nimble-therapeutics or visit our website at www.nimbletherapeutics.com to learn more.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here:

https://www.businesswire.com/news/home/20221129005339/en/Nimble-Therapeutics-names-Pete-Gough-as-Chief-Scientific-Officer

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News Partnering Press Release

Nimble Therapeutics Announces Achievement of Development Milestones from Multiple Partnered Programs Connected to a Strategic Large Pharma Collaboration

MADISON, Wis.–Nimble Therapeutics Inc. today announced the company has achieved the first development milestone for each of several programs attached to a multi-target collaboration with an undisclosed large pharma partner.

Nimble will receive payments for each milestone connected to the collaboration, and the company remains eligible for additional future downstream milestones attached to each program as development continues.

“This is a significant accomplishment for our young company as we work with our partners to create important medicines for the benefit of patients, and we look forward to supporting this partner as they continue the development activities for each program.” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics.

“Delivering lead candidates to one of our first partners validates the power of our platform, approach, and team; and clearly demonstrates the value that Nimble brings to its partners. We are working diligently to deliver state of the art peptides for each and every partnered program and are confident that these efforts will result in additional milestones being earned by Nimble in 2022, and beyond.”

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble integrates the unrivaled chemical and structural diversity of its proprietary, light-directed, massively parallel solid-phase synthesis with biological display techniques, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics. For more information please see www.nimbletherapeutics.com.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20220517005323/en/Nimble-Therapeutics-Announces-Achievement-of-Development-Milestones-From-Multiple-Partnered-Programs-Connected-to-a-Strategic-Large-Pharma-Collaboration

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News Partnering Press Release

Nimble Therapeutics and Incyte Expand their Strategic Research Collaboration to Discover Additional Novel Peptide Therapeutics

Madison, WI, USA September 14, 2021 Nimble Therapeutics, a biotechnology company revolutionizing the discovery and development of peptide therapeutics, today announced their strategic research collaboration with Incyte (NASDAQ: INCY) has been expanded to include discovery of additional novel peptide therapies.

“Nimble looks forward to building upon on the already strong collaboration between the Nimble and Incyte scientific teams. The expansion of the collaboration serves as yet another important validation of Nimble’s powerful capabilities and approach towards engineering the next generation of peptide therapeutics”, said Jigar Patel, CEO and Founder of Nimble Therapeutics.

Under the terms of the agreement, Nimble will receive an upfront payment and reimbursement of certain research program costs and may become eligible for downstream milestone payments and royalties. Incyte has exclusive rights to develop and commercialize any peptides discovered under the collaboration and has an option to further expand the collaboration to include additional targets.

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics.

Connect with us on LinkedIn at www.linkedin.com/company/nimble-therapeutics or visit our website at www.nimbletherapeutics.com to learn more.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20210914005143/en/Nimble-Therapeutics-and-Incyte-Expand-their-Strategic-Research-Collaboration-to-Discover-Additional-Novel-Peptide-Therapeutics

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News Press Release

Nimble Therapeutics Appoints Cyrus Arman, PhD, MBA as Chief Business Officer

Madison, WI, USA September 08, 2021 — Nimble Therapeutics, an industry-leading peptide therapeutic discovery and optimization company, today announced the appointment of Dr. Cyrus Arman as Chief Business Officer. Cyrus will be responsible for structuring strategic alliances, licensing agreements, and financial investments, and will further provide management and strategic leadership to the organization. The appointment comes at a time of significant growth for Nimble Therapeutics, as the company continues to advance its technology platform and build out its strategic partnerships. His appointment represents the first step in Nimble’s expansion toward becoming a fully integrated biotechnology company.

Cyrus has over 12 years of experience in corporate, clinical, and commercial strategy. Most recently, he served as Vice President of Corporate Development and Strategy at NEUVOGEN, Inc, an immuno-oncology firm developing cancer vaccines. Prior to NEUVOGEN, Dr. Arman contributed to rebuilding and running Amgen’s Global Competitive Intelligence and Strategy unit, and later served as a Director in Amgen’s Corporate Strategy group.

“We’re excited to welcome Cyrus to our management team at Nimble,” said Jigar Patel, PhD, Founder and CEO of Nimble Therapeutics. “Cyrus brings valuable experience devising strategy, executing transactions, and leveraging innovation that will enable Nimble to deliver on the promise of peptide therapeutics.”

Cyrus has an MBA from the University of California Los Angeles, a PhD in Neuroscience and an MS in Biomedical Engineering from the University of Southern California, and a BS in Biopsychology from the University of California San Diego.

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics.

Connect with us on LinkedIn at www.linkedin.com/company/nimble-therapeutics or visit our website at www.nimbletherapeutics.com to learn more.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20210908005289/en/Nimble-Therapeutics-Appoints-Cyrus-Arman-PhD-MBA-as-Chief-Business-Officer

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News Partnering Press Release

Nimble Therapeutics and RayzeBio Announce Strategic Research Collaboration to Discover & Develop Novel Peptide-Based Radiopharmaceuticals

Madison, WI, USA, & San Diego, CA, USA June 28, 2021 — Nimble Therapeutics and RayzeBio today announced the companies have entered a strategic collaboration to discover and develop novel peptide-based radiopharmaceuticals for treatment of cancer.

“We are excited to welcome RayzeBio to our growing family of partners” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics. “Through our pioneering work, we have built a platform to rapidly identify drug-like hits and optimize them into leads, and conduct elaborate medicinal chemistry campaigns to engineer candidates with optimal potency, selectivity, stability, and other important attributes. This agreement with RayzeBio underscores the value inherent in Nimble’s platform to advancing the radiopharmaceutical field.”

“Nimble’s platform technology is promising,” said Ken Song, M.D., CEO of RayzeBio. “Nimble’s rational approach to using its platform to identify novel peptide-like molecules allows us to further expand our radiopharmaceutical pipeline and pursue multiple therapeutic programs in parallel.”

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment, research reimbursements and may also receive further milestone payments and royalties on sales of resulting products. RayzeBio has exclusive rights to develop and commercialize peptides discovered under the collaboration, and an option to further expand the collaboration to include additional targets.

About Nimble Therapeutics
Nimble Therapeutics is a biotechnology company revolutionizing the discovery & development of peptide therapeutics. The company’s discovery platform integrates leading-edge peptide synthesis, bioinformatic and chemoinformatic tools, a variety of naïve and scaffolded chemical libraries, custom screening and validation assays, and accelerated medicinal chemistry. The company has established partnerships with leading pharmaceutical and biotech companies, and seeks to leverage its technology across many therapeutic areas. For more information, please visit www.nimbletherapeutics.com.

About RayzeBio
RayzeBio is a biotechnology company focused on improving outcomes for people with cancer by harnessing the power of targeted radioisotopes. With a focus on clinically validated solid tumor targets, RayzeBio is developing novel peptide mimetic binders to deliver potent therapeutic radioisotopes such as Actinium-225, an alpha-emitter. The company is backed by a syndicate of sophisticated healthcare investors and was established in 2020. For additional information, please visit www.rayzebio.com.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, Ph.D.
Vice President, Corporate Development
info@nimbletherapeutics.com

RayzeBio, Inc.
Ken Song, M.D.
President and CEO
info@rayzebio.com

View the full press release here: https://www.businesswire.com/news/home/20210628005106/en/Nimble-Therapeutics-and-RayzeBio-Announce-Strategic-Research-Collaboration-to-Discover-Develop-Novel-Peptide-Based-Radiopharmaceuticals

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News Partnering Press Release

Nimble Announces Strategic Research Collaboration with Incyte to Discover Novel Peptide-Based Therapeutics

Madison, WI, USA, Oct. 5, 2020 — Nimble Therapeutics Inc. today announced the company has entered into a strategic collaboration with Incyte (NASDAQ: INCY) to discover first-in-class peptide therapies across various disease areas.

“This is an important collaboration for both companies to discover novel peptide based therapeutics,” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics. “We are excited to partner with Incyte, an organization with world-class drug discovery, development and commercialization capabilities, to ensure maximal patient impact across multiple disease indications.”

The collaboration will leverage Nimble’s proprietary peptide synthesis, screening and optimization platform, coupled with its high chemical diversity and integrated suite of assays to enable faster discovery and optimization of promising compounds for intracellular and extracellular targets.

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment, reimbursement of certain research program costs and may become eligible for downstream milestone payments and royalties. Incyte has exclusive rights to develop and commercialize any peptides discovered under the collaboration, and an option to further expand the collaboration to include additional targets.

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Press Release

Nimble Announces Collaboration to Discover and Develop Novel Peptide-Based Compounds for SARS-CoV-2 Diagnostics

Madison, WI, USA. May 6, 2020 — Nimble Therapeutics, Inc. today announced a collaboration with Roche Diagnostics to accelerate discovery of novel peptide-based molecules for the development of SARS-CoV-2 in vitro diagnostic assays.

Nimble will extend its proprietary peptide synthesis, screening and optimization platform to enable faster discovery and optimization of promising compounds for detecting SARS-CoV-2. Roche will leverage its world-class capabilities to develop in vitro diagnostic assays for rapid detection of SARS-CoV-2.

“We are extremely motivated to partner with Roche to tackle this global COVID-19 health crisis” said Jigar Patel, Ph.D., Chief Executive Officer of Nimble Therapeutics. “This partnership expands our discovery capabilities, demonstrating the power and breadth of the Nimble platform in rapidly discovering novel compounds.”

Terms of the agreement are not being disclosed.

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Press Release

Nimble & Svar Life Science Announce Collaboration to Discover, Develop and Commercialize Diagnostic Tests based on Nimble’s Novel Biomarker Discovery Engine

Madison, WI, USA and Malmö, SE. Apr. 16, 2020 — Nimble Therapeutics and Svar Life Science today announced a collaboration to discover, develop, and commercialize diagnostic tests based on Nimble’s powerful and broadly applicable biomarker discovery engine and Svar’s strong in vitro diagnostic test development and commercialization expertise.

The collaboration initially will leverage a novel panel of rheumatoid arthritis biomarkers discovered using Nimble’s comprehensive human proteome immunoprofiling.

“We are excited to partner with a leading, well-respected life science company like Svar. Their reputation for high-quality tests and strong global presence makes them an ideal partner for Nimble.” said Jigar Patel, Ph.D., Chief Executive Officer of Nimble Therapeutics. “This collaboration combines the strengths of our two organizations to potentially bring new and improved tests to patients with autoimmune disorders.”

Bradley Garcia, Nimble’s VP of Corporate Development notes, “This collaboration is validation of Nimble’s powerful discovery platform and partnering with Svar provides a strong commercial outlet for Nimble’s discovery capabilities”.

Svar Life Science has a strong track record in pioneering new solutions within clinical diagnostics and drug discovery. For over 30 years, Svar has been working across the clinical diagnostic value chain, with a special focus on autoimmunity, IBD and rheumatoid arthritis.

“We are delighted to partner with an innovative and entrepreneurial company like Nimble Therapeutics. Their powerful, cutting edge biomarker discovery platform in combination with our experience and expertise creates a strong foundation and supports our strategy to bring forward novel solutions to improve clinical outcome of patients” says Jörgen Dahlström, Ph.D., Chief Executive Officer of Svar Life Science.

“This agreement exemplifies how we collaborate with innovative companies to discover, develop and commercialize solutions which support drug development and enable clinical diagnosis” notes Frida Pauly, Director Business Development at Svar.

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment and will be eligible for downstream milestone payments and royalties on product sales.

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Press Release

Nimble Announces Collaboration with Genentech to Discover and Develop Novel Peptide-Based Therapeutics

Madison, WI, USA, Feb. 19, 2020 — Nimble Therapeutics, Inc. today announced a multi-year collaboration with Genentech, a member of the Roche Group, to accelerate discovery and development of novel peptide-based medicines for targets across a range of diseases.

The collaboration will leverage Nimble’s proprietary peptide synthesis, screening and optimization platform, chemical diversity, and integrated suite of assays to enable faster discovery and optimization of promising compounds for intracellular and extracellular targets.

“We are excited to collaborate with a world class and well-respected organization such as Genentech to identify novel peptide therapeutics,” said Jigar Patel, Ph.D., Chief Executive Officer of Nimble Therapeutics. “This partnership combines the strengths of our two organizations to potentially bring new medicines to patients.”

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment and will be eligible for downstream milestone payments and royalties.

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News Press Release

Nimble Therapeutics Spins Out from Roche to Commercialize Novel Drug Discovery Technology with Financing from Telegraph Hill Partners

April 30, 2019 (Madison, WI): Nimble Therapeutics has begun operating as a standalone business after spinning out from F. Hoffmann La Roche (SIX: RO, ROG; OTCQX: RHHBY) to commercialize its proprietary chemical synthesis technology for drug discovery and development. The company also completed a Series A financing led by Telegraph Hill Partners (San Francisco, CA).

Initially, Nimble Therapeutics will leverage the unparalleled speed and flexibility of its proprietary chemical synthesis platform, developed at Roche, to accelerate the discovery and optimization of macrocyclic peptidomimetics as novel therapeutics. “As a fully independent company, Nimble Therapeutics will establish strategic partnerships with pharmaceutical companies to jointly develop unique drug candidates more efficiently across many therapeutic areas”, notes Dr. Jigar Patel, who led the development of the technology and will serve as CEO of the company.

Nimble Therapeutics has hired the former Roche team that helped develop its chemical synthesis technology for drug discovery. The company’s platform, validated over many years and with over 20+ collaborations, provides the ability to synthesize millions of unique natural and modified peptide-based molecules simultaneously. These molecules can be efficiently screened and optimized through rapid iterations to identify novel entities with the desired characteristics using the Nimble platform.

As part of its growth strategy, the company will expand its current collaborations and strategically develop new relationships in key therapeutic areas. “The Roche team saw the value in separating the business to enable it to expand its platform and work on a variety of therapeutic areas with strategic partners”, said Dr. Deval Lashkari, Senior Partner at Telegraph Hill Partners and board director at Nimble Therapeutics, “Nimble’s capabilities are truly revolutionary and we are excited to work with the company in a shared vision to grow the business into a leading drug discovery partner for the pharmaceutical industry.”