Category: Press Release

Nimble Therapeutics Announces Expansion of its Discovery and Development Partnership with Genentech

Post author By Holly Katt
Post date January 5, 2023

MADISON, Wis.–(BUSINESS WIRE)–Nimble Therapeutics, a biotechnology company leveraging its next-generation peptide discovery platform to identify medicines for challenging-to-drug targets, today announced that the company has expanded its collaboration and executed a license agreement with Genentech, a member of the Roche Group (SIX:RO, ROG; OTCQX: RHHBY), for the discovery of peptide therapies for the treatment of diseases across multiple therapeutic areas.

“We are excited to significantly expand our partnership and strengthen our collaboration with Genentech,” said Jigar Patel, Founder & CEO of Nimble Therapeutics. “Genentech has been a valuable strategic partner and we are proud that our success thus far has led to the opportunity to significantly broaden our work together with both Genentech and Roche.”

Under the terms of the agreement, Nimble will receive a $20 million upfront payment; near-term, preclinical, clinical, and commercial milestone payments that could exceed $1.1 billion; as well as tiered royalties. Nimble will apply its platform against multiple targets, and Genentech and Roche will be responsible for preclinical and clinical development, and commercialization of any resulting products.

“This expanded partnership with Genentech, and the multiple recently achieved milestones across all our partnered programs, demonstrates Nimble’s capability to deliver peptide therapeutic candidates,” said Pete Gough, CSO of Nimble Therapeutics. “We are excited to further leverage our differentiated platform to accelerate development of optimized candidates against a larger set of novel targets in partnership with Genentech.”

“Given the success of our initial collaboration, we look forward to deepening our partnership with Nimble as we work together against a larger number of important and challenging targets across various disease areas,” said James Sabry, Global Head of Roche Pharma Partnering.

About Nimble Therapeutics

Nimble is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to discover and develop next generation peptide therapeutics efficiently and intelligently. Nimble has extensively validated its platform to identify highly biologically active compounds for multiple programs, spanning a wide variety of therapeutic target classes. For more information, visit www.nimbletherapeutics.com.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, Ph.D.
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20230105005173/en/Nimble-Therapeutics-Announces-Expansion-of-its-Discovery-and-Development-Partnership-with-Genentech

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News Partnering Press Release

Nimble Therapeutics Delivers Lead Compounds for Two Programs Under Collaboration with Large Pharma Partner, Triggering Milestone Payments

Post author By Holly Katt
Post date December 13, 2022

MADISON, WI, USA, December 13, 2022 — Nimble Therapeutics Inc., a leading peptide therapeutics company, today announced they have achieved discovery milestones for two programs partnered with a large pharma company. For each program, Nimble has delivered lead compounds ready for further pre-clinical testing and subsequent IND studies. As with all its partnered research programs, Nimble remains eligible for additional future pre-clinical, clinical, and commercial milestones, and royalties attached to each program as development progresses.

In the last nine months alone, Nimble has delivered lead compounds for four programs to its partners. This progress, across multiple targets and partners, validates the power of Nimble’s platform to optimize peptide therapeutics at unprecedented speed. In addition to Nimble’s core platform technology, Nimble continues to expand its internal R&D capabilities, with work ongoing to advance its wholly owned pipeline. This effort is being led by pharmaceutical industry veteran Pete Gough, D.Phil., who joined as the company’s Chief Scientific Officer in November.

“Nimble’s demonstrated ability to consistently reach these important milestones is a testament to the strength of the scientific collaborations we have built with our partners and our powerful drug discovery and development engine and team,” said Jigar Patel, CEO. “We remain committed to working diligently with each of our partners to bring important medicines to patients.” Patel added that, “Nimble continues to advance its own internal pipeline while also evaluating strategic partnering opportunities for 2023 and beyond.”

About Nimble Therapeutics

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, Ph.D.
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20221213005335/en/Nimble-Therapeutics-Delivers-Lead-Compounds-for-Two-Programs-Under-Collaboration-with-Large-Pharma-Partner-Triggering-Milestone-Payments

News Press Release

Nimble Therapeutics names Pete Gough as Chief Scientific Officer

Post author By Holly Katt
Post date November 30, 2022

Madison, WI, USA — November 30, 2022 — Nimble Therapeutics, an industry-leading peptide therapeutics company, today announced the appointment of Pete Gough, D. Phil. as Chief Scientific Officer (CSO). In this newly created role, Dr. Gough will spearhead the expansion of Nimble’s internal drug discovery capabilities that will enable further development of its own pipeline of proprietary therapeutics and drive Nimble towards becoming a fully integrated biotechnology company.

Dr. Gough has more than 25 years of experience in discovery research, both in academic settings as well as in the life sciences industry, and a track record of success in drug discovery and development, driving research programs into clinical study by building and leading high-performance teams. Prior to joining Nimble, Pete served as the CSO for Inzen Therapeutics, a Flagship company pioneering the newly discovered science of Thanokine Biology. At Inzen, he helped advance the company from seed stage to a successful Series B through the development of their pipeline of potentially transformational Immuno-Oncology therapeutics. Previously, Pete spent 15 years at GSK in roles of increasing responsibility. He served as Head of the Hepatitis B Virus Discovery Performance Unit (DPU) where he led GSK’s efforts to develop a functional cure for HBV including proof of concept studies for bepirovirsen. He also served as Head of the Host Defense DPU, and prior to that was Head of Biology and DMPK in the Pattern Recognition Receptor DPU. Pete led, and oversaw, the discovery and development of a number of clinical assets across multiple therapeutic areas including RIP1 kinase inhibitor GSK2982772 and STING agonist GSK3745417.

“We’re excited to welcome Pete to our management team at Nimble,” said Jigar Patel, PhD, Founder and CEO of Nimble Therapeutics. “Since our formation in 2019, Nimble has worked diligently to optimize and validate our peptide discovery platform. Pete brings invaluable experience in drug discovery and development across multiple therapeutic areas that will enable Nimble to deliver on the promise of peptide therapeutics through progressing and expanding our own internal pipeline.”

“Nimble has built the industry leading platform for discovering peptide therapeutics that solves for the challenges that everyone else in the field is struggling with,” said Dr. Gough. “I’m very excited to be part of the team and to help realize the truly transformative nature of the Nimble platform by advancing novel medicines into the clinic.”

Earlier in his career, Pete was a Research Assistant Professor in the Department of Pathology at the University of Washington. He received his D. Phil. and M. A. from the University of Oxford. Pete has authored/co-authored over 100 scientific papers in peer-reviewed journals and has been an invited speaker at numerous academic institutions and scientific conferences.

About Nimble Therapeutics

Nimble is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics. Nimble has extensively validated its platform to identify highly biologically active compounds for multiple programs, spanning a wide variety of therapeutic target classes.

Connect with us on LinkedIn at www.linkedin.com/company/nimble-therapeutics or visit our website at www.nimbletherapeutics.com to learn more.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here:

https://www.businesswire.com/news/home/20221129005339/en/Nimble-Therapeutics-names-Pete-Gough-as-Chief-Scientific-Officer

News Partnering Press Release

Nimble Therapeutics Announces Achievement of Development Milestones from Multiple Partnered Programs Connected to a Strategic Large Pharma Collaboration

Post author By Holly Katt
Post date May 17, 2022

MADISON, Wis.–Nimble Therapeutics Inc. today announced the company has achieved the first development milestone for each of several programs attached to a multi-target collaboration with an undisclosed large pharma partner.

Nimble will receive payments for each milestone connected to the collaboration, and the company remains eligible for additional future downstream milestones attached to each program as development continues.

“This is a significant accomplishment for our young company as we work with our partners to create important medicines for the benefit of patients, and we look forward to supporting this partner as they continue the development activities for each program.” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics.

“Delivering lead candidates to one of our first partners validates the power of our platform, approach, and team; and clearly demonstrates the value that Nimble brings to its partners. We are working diligently to deliver state of the art peptides for each and every partnered program and are confident that these efforts will result in additional milestones being earned by Nimble in 2022, and beyond.”

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble integrates the unrivaled chemical and structural diversity of its proprietary, light-directed, massively parallel solid-phase synthesis with biological display techniques, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics. For more information please see www.nimbletherapeutics.com.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20220517005323/en/Nimble-Therapeutics-Announces-Achievement-of-Development-Milestones-From-Multiple-Partnered-Programs-Connected-to-a-Strategic-Large-Pharma-Collaboration

News Partnering Press Release

Nimble Therapeutics and Incyte Expand their Strategic Research Collaboration to Discover Additional Novel Peptide Therapeutics

Post author By Holly Katt
Post date September 14, 2021

Madison, WI, USA — September 14, 2021 — Nimble Therapeutics, a biotechnology company revolutionizing the discovery and development of peptide therapeutics, today announced their strategic research collaboration with Incyte (NASDAQ: INCY) has been expanded to include discovery of additional novel peptide therapies.

“Nimble looks forward to building upon on the already strong collaboration between the Nimble and Incyte scientific teams. The expansion of the collaboration serves as yet another important validation of Nimble’s powerful capabilities and approach towards engineering the next generation of peptide therapeutics”, said Jigar Patel, CEO and Founder of Nimble Therapeutics.

Under the terms of the agreement, Nimble will receive an upfront payment and reimbursement of certain research program costs and may become eligible for downstream milestone payments and royalties. Incyte has exclusive rights to develop and commercialize any peptides discovered under the collaboration and has an option to further expand the collaboration to include additional targets.

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics.

Connect with us on LinkedIn at www.linkedin.com/company/nimble-therapeutics or visit our website at www.nimbletherapeutics.com to learn more.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20210914005143/en/Nimble-Therapeutics-and-Incyte-Expand-their-Strategic-Research-Collaboration-to-Discover-Additional-Novel-Peptide-Therapeutics

News Press Release

Nimble Therapeutics Appoints Cyrus Arman, PhD, MBA as Chief Business Officer

Post author By Holly Katt
Post date September 8, 2021

Madison, WI, USA — September 08, 2021 — Nimble Therapeutics, an industry-leading peptide therapeutic discovery and optimization company, today announced the appointment of Dr. Cyrus Arman as Chief Business Officer. Cyrus will be responsible for structuring strategic alliances, licensing agreements, and financial investments, and will further provide management and strategic leadership to the organization. The appointment comes at a time of significant growth for Nimble Therapeutics, as the company continues to advance its technology platform and build out its strategic partnerships. His appointment represents the first step in Nimble’s expansion toward becoming a fully integrated biotechnology company.

Cyrus has over 12 years of experience in corporate, clinical, and commercial strategy. Most recently, he served as Vice President of Corporate Development and Strategy at NEUVOGEN, Inc, an immuno-oncology firm developing cancer vaccines. Prior to NEUVOGEN, Dr. Arman contributed to rebuilding and running Amgen’s Global Competitive Intelligence and Strategy unit, and later served as a Director in Amgen’s Corporate Strategy group.

“We’re excited to welcome Cyrus to our management team at Nimble,” said Jigar Patel, PhD, Founder and CEO of Nimble Therapeutics. “Cyrus brings valuable experience devising strategy, executing transactions, and leveraging innovation that will enable Nimble to deliver on the promise of peptide therapeutics.”

Cyrus has an MBA from the University of California Los Angeles, a PhD in Neuroscience and an MS in Biomedical Engineering from the University of Southern California, and a BS in Biopsychology from the University of California San Diego.

About Nimble Therapeutics

Nimble Therapeutics is a biotechnology company dedicated to delivering on the promise of peptide therapeutics. Leveraging a paradigm-shifting peptide drug discovery and development engine, Nimble combines massively parallel solid-phase synthesis, unrivaled chemical and structural diversity, sophisticated assays, and powerful analytics to efficiently and intelligently discover and develop next generation peptide therapeutics.

Connect with us on LinkedIn at www.linkedin.com/company/nimble-therapeutics or visit our website at www.nimbletherapeutics.com to learn more.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, PhD
Vice President, Corporate Development
info@nimbletherapeutics.com

View the full press release here: https://www.businesswire.com/news/home/20210908005289/en/Nimble-Therapeutics-Appoints-Cyrus-Arman-PhD-MBA-as-Chief-Business-Officer

News Partnering Press Release

Nimble Therapeutics and RayzeBio Announce Strategic Research Collaboration to Discover & Develop Novel Peptide-Based Radiopharmaceuticals

Post author By Holly Katt
Post date June 28, 2021

Madison, WI, USA, & San Diego, CA, USA June 28, 2021 — Nimble Therapeutics and RayzeBio today announced the companies have entered a strategic collaboration to discover and develop novel peptide-based radiopharmaceuticals for treatment of cancer.

“We are excited to welcome RayzeBio to our growing family of partners” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics. “Through our pioneering work, we have built a platform to rapidly identify drug-like hits and optimize them into leads, and conduct elaborate medicinal chemistry campaigns to engineer candidates with optimal potency, selectivity, stability, and other important attributes. This agreement with RayzeBio underscores the value inherent in Nimble’s platform to advancing the radiopharmaceutical field.”

“Nimble’s platform technology is promising,” said Ken Song, M.D., CEO of RayzeBio. “Nimble’s rational approach to using its platform to identify novel peptide-like molecules allows us to further expand our radiopharmaceutical pipeline and pursue multiple therapeutic programs in parallel.”

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment, research reimbursements and may also receive further milestone payments and royalties on sales of resulting products. RayzeBio has exclusive rights to develop and commercialize peptides discovered under the collaboration, and an option to further expand the collaboration to include additional targets.

About Nimble Therapeutics
Nimble Therapeutics is a biotechnology company revolutionizing the discovery & development of peptide therapeutics. The company’s discovery platform integrates leading-edge peptide synthesis, bioinformatic and chemoinformatic tools, a variety of naïve and scaffolded chemical libraries, custom screening and validation assays, and accelerated medicinal chemistry. The company has established partnerships with leading pharmaceutical and biotech companies, and seeks to leverage its technology across many therapeutic areas. For more information, please visit www.nimbletherapeutics.com.

About RayzeBio
RayzeBio is a biotechnology company focused on improving outcomes for people with cancer by harnessing the power of targeted radioisotopes. With a focus on clinically validated solid tumor targets, RayzeBio is developing novel peptide mimetic binders to deliver potent therapeutic radioisotopes such as Actinium-225, an alpha-emitter. The company is backed by a syndicate of sophisticated healthcare investors and was established in 2020. For additional information, please visit www.rayzebio.com.

Media Contact

Nimble Therapeutics, Inc.
Brad Garcia, Ph.D.
Vice President, Corporate Development
info@nimbletherapeutics.com

RayzeBio, Inc.
Ken Song, M.D.
President and CEO
info@rayzebio.com

View the full press release here: https://www.businesswire.com/news/home/20210628005106/en/Nimble-Therapeutics-and-RayzeBio-Announce-Strategic-Research-Collaboration-to-Discover-Develop-Novel-Peptide-Based-Radiopharmaceuticals

News Partnering Press Release

Nimble Announces Strategic Research Collaboration with Incyte to Discover Novel Peptide-Based Therapeutics

Post author By Holly Katt
Post date October 5, 2020
No Comments on Nimble Announces Strategic Research Collaboration with Incyte to Discover Novel Peptide-Based Therapeutics

Madison, WI, USA, Oct. 5, 2020 — Nimble Therapeutics Inc. today announced the company has entered into a strategic collaboration with Incyte (NASDAQ: INCY) to discover first-in-class peptide therapies across various disease areas.

“This is an important collaboration for both companies to discover novel peptide based therapeutics,” said Jigar Patel, Ph.D., CEO of Nimble Therapeutics. “We are excited to partner with Incyte, an organization with world-class drug discovery, development and commercialization capabilities, to ensure maximal patient impact across multiple disease indications.”

The collaboration will leverage Nimble’s proprietary peptide synthesis, screening and optimization platform, coupled with its high chemical diversity and integrated suite of assays to enable faster discovery and optimization of promising compounds for intracellular and extracellular targets.

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment, reimbursement of certain research program costs and may become eligible for downstream milestone payments and royalties. Incyte has exclusive rights to develop and commercialize any peptides discovered under the collaboration, and an option to further expand the collaboration to include additional targets.

Press Release

Nimble Announces Collaboration to Discover and Develop Novel Peptide-Based Compounds for SARS-CoV-2 Diagnostics

Post author By Holly Katt
Post date May 6, 2020
No Comments on Nimble Announces Collaboration to Discover and Develop Novel Peptide-Based Compounds for SARS-CoV-2 Diagnostics

Madison, WI, USA. May 6, 2020 — Nimble Therapeutics, Inc. today announced a collaboration with Roche Diagnostics to accelerate discovery of novel peptide-based molecules for the development of SARS-CoV-2 in vitro diagnostic assays.

Nimble will extend its proprietary peptide synthesis, screening and optimization platform to enable faster discovery and optimization of promising compounds for detecting SARS-CoV-2. Roche will leverage its world-class capabilities to develop in vitro diagnostic assays for rapid detection of SARS-CoV-2.

“We are extremely motivated to partner with Roche to tackle this global COVID-19 health crisis” said Jigar Patel, Ph.D., Chief Executive Officer of Nimble Therapeutics. “This partnership expands our discovery capabilities, demonstrating the power and breadth of the Nimble platform in rapidly discovering novel compounds.”

Terms of the agreement are not being disclosed.

Press Release

Nimble & Svar Life Science Announce Collaboration to Discover, Develop and Commercialize Diagnostic Tests based on Nimble’s Novel Biomarker Discovery Engine

Madison, WI, USA and Malmö, SE. Apr. 16, 2020 — Nimble Therapeutics and Svar Life Science today announced a collaboration to discover, develop, and commercialize diagnostic tests based on Nimble’s powerful and broadly applicable biomarker discovery engine and Svar’s strong in vitro diagnostic test development and commercialization expertise.

The collaboration initially will leverage a novel panel of rheumatoid arthritis biomarkers discovered using Nimble’s comprehensive human proteome immunoprofiling.

“We are excited to partner with a leading, well-respected life science company like Svar. Their reputation for high-quality tests and strong global presence makes them an ideal partner for Nimble.” said Jigar Patel, Ph.D., Chief Executive Officer of Nimble Therapeutics. “This collaboration combines the strengths of our two organizations to potentially bring new and improved tests to patients with autoimmune disorders.”

Bradley Garcia, Nimble’s VP of Corporate Development notes, “This collaboration is validation of Nimble’s powerful discovery platform and partnering with Svar provides a strong commercial outlet for Nimble’s discovery capabilities”.

Svar Life Science has a strong track record in pioneering new solutions within clinical diagnostics and drug discovery. For over 30 years, Svar has been working across the clinical diagnostic value chain, with a special focus on autoimmunity, IBD and rheumatoid arthritis.

“We are delighted to partner with an innovative and entrepreneurial company like Nimble Therapeutics. Their powerful, cutting edge biomarker discovery platform in combination with our experience and expertise creates a strong foundation and supports our strategy to bring forward novel solutions to improve clinical outcome of patients” says Jörgen Dahlström, Ph.D., Chief Executive Officer of Svar Life Science.

“This agreement exemplifies how we collaborate with innovative companies to discover, develop and commercialize solutions which support drug development and enable clinical diagnosis” notes Frida Pauly, Director Business Development at Svar.

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment and will be eligible for downstream milestone payments and royalties on product sales.