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Nimble Announces Collaboration with Genentech to Discover and Develop Novel Peptide-Based Therapeutics

Madison, WI, USA, Feb. 19, 2020 — Nimble Therapeutics, Inc. today announced a multi-year collaboration with Genentech, a member of the Roche Group, to accelerate discovery and development of novel peptide-based medicines for targets across a range of diseases.

The collaboration will leverage Nimble’s proprietary peptide synthesis, screening and optimization platform, chemical diversity, and integrated suite of assays to enable faster discovery and optimization of promising compounds for intracellular and extracellular targets.

“We are excited to collaborate with a world class and well-respected organization such as Genentech to identify novel peptide therapeutics,” said Jigar Patel, Ph.D., Chief Executive Officer of Nimble Therapeutics. “This partnership combines the strengths of our two organizations to potentially bring new medicines to patients.”

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment and will be eligible for downstream milestone payments and royalties.

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Nimble Therapeutics Spins Out from Roche to Commercialize Novel Drug Discovery Technology with Financing from Telegraph Hill Partners

April 30, 2019 (Madison, WI): Nimble Therapeutics has begun operating as a standalone business after spinning out from F. Hoffmann La Roche (SIX: RO, ROG; OTCQX: RHHBY) to commercialize its proprietary chemical synthesis technology for drug discovery and development. The company also completed a Series A financing led by Telegraph Hill Partners (San Francisco, CA).

Initially, Nimble Therapeutics will leverage the unparalleled speed and flexibility of its proprietary chemical synthesis platform, developed at Roche, to accelerate the discovery and optimization of macrocyclic peptidomimetics as novel therapeutics. “As a fully independent company, Nimble Therapeutics will establish strategic partnerships with pharmaceutical companies to jointly develop unique drug candidates more efficiently across many therapeutic areas”, notes Dr. Jigar Patel, who led the development of the technology and will serve as CEO of the company.

Nimble Therapeutics has hired the former Roche team that helped develop its chemical synthesis technology for drug discovery. The company’s platform, validated over many years and with over 20+ collaborations, provides the ability to synthesize millions of unique natural and modified peptide-based molecules simultaneously. These molecules can be efficiently screened and optimized through rapid iterations to identify novel entities with the desired characteristics using the Nimble platform.

As part of its growth strategy, the company will expand its current collaborations and strategically develop new relationships in key therapeutic areas. “The Roche team saw the value in separating the business to enable it to expand its platform and work on a variety of therapeutic areas with strategic partners”, said Dr. Deval Lashkari, Senior Partner at Telegraph Hill Partners and board director at Nimble Therapeutics, “Nimble’s capabilities are truly revolutionary and we are excited to work with the company in a shared vision to grow the business into a leading drug discovery partner for the pharmaceutical industry.”