Optimizing oral medications requires a deep understanding of potency, stability, gut permeability, half-life, and metabolism. We’ve assembled a range of integrated approaches to accelerate the discovery and development of life-changing oral treatments.
- We employ a multifaceted approach for hit identification, combining mRNA and phage display techniques along with fit-for-purpose chemically synthesized libraries that span natural and non-natural chemical spaces.
- Our approach allows us to comprehensively examine a diverse range of molecular conformations, encompassing both linear and cyclic structures. This includes molecules that are cyclized through disulfide bonds, thioether linkages, head-to-tail interactions, as well as bicyclic, tricyclic, and branched scaffolds.
- By leveraging our platform’s insights, we can systematically exploit the deep structural activity relationships (SAR) present in our data, regardless of whether we have prior knowledge of a molecule’s structure.
- Our data-driven lead optimization process is designed to systematically enhance key properties essential for oral medications. This includes the integration of cutting-edge software and algorithms that enable rapid analysis of vast datasets.
- We leverage advanced structural biology methods like X-ray crystallography and cryogenic electron microscopy, as well as pharmacokinetic/pharmacodynamic-centric strategies, to optimize lead compounds.
- In addition, we have access to in vivo models through our translational biology capabilities, ensuring seamless translation from discovery to development.
