Our Approach

We use our unique maskless chemical synthesis platform to synthesize and systematically discover novel medicines with optimal properties in a variety of therapeutic areas.

Infinite Choice. Untethered Discovery.

Nimble Therapeutics is using an iterative, data driven approach and an extensive in-house monomer library to navigate through a chemical space many orders of magnitude larger than what has previously been available.

We are experts in navigating this vast chemical space to systematically explore molecular attributes. This uniquely positions Nimble to engineer molecules with optimized pharmaceutical properties across many disease indications.

 

Amide-bond based compounds are systematically engineered using a vast scale and chemical diversity of our amino acid library. Our catalog of photoprotected amino acids spans both natural and non-natural amino acids including L-, D-, beta, gamma, and N-methyl monomers. We incorporate additional chemical reactions and orthogonal protecting groups to access unique molecular architectures. Nimble libraries are systematically designed using chemical matter that is either discovered or designed specifically with a target’s profile in mind.

Integrated Capabilities

Design

Nimble Therapeutics’ proprietary chemical language enables rapid and efficient implementation of design concepts into a set of complete instructions for fully automated, massively parallel library synthesis. These custom-built tools are deeply integrated with our high-precision, fully automated, light-directed chemical synthesis platform.  Together, this enables Nimble to design libraries unique to each target and encompassing a chemical space bounded only by imagination.

Features

  • Bespoke library designs are tailored to the target of interest and its unique attributes.
  • Vast design space reflects flexibility of chemical synthesis platform and encompasses diverse building blocks, chemical bonds, molecules sizes, and compositions
  • Designs draw on deep in-house catalog of >350 chemical building blocks
  • Compatible with Nimble’s proprietary Display-to-Array (D2A) technology

Additional Information & Resources

Explore some design concepts & core implementation of our platform.

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Synthesis

Inspired by traditional solid-phase synthesis, Nimble Therapeutics’ proprietary instrumentation represents a sophisticated integration of photolithography, precision optics, fluidics, and automation.  Our platform enables exquisite combinatorial synthesis of tailor-made libraries in a matter of hours from up to hundreds of different monomers, in linear cyclic and branched conformations.

Features

  • Robust, fully automated synthesis of custom libraries with integrated quality controls
  • Solid-phase synthesis leveraging orthogonal and proprietary photo-protection chemistry
  • Seamless integration with Nimble’s custom-built informatics and assays

Additional Information & Resources

Fragment Based Discovery
Protein-Protein Disruptor Discovery
Rapid Phage Single-Step Selection & Step-Wise Array Optimization
Small Branched & Cyclic Peptide Discovery Libraries
Scaffolded alpha helical, beta hairpins Discovery Libraries

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Assays

Nimble Therapeutics’ veteran team has developed and implemented biological assays for massively parallel screening and optimization of peptides towards molecules with pharmaceutically relevant properties. Our ability to explore and interrogate multiple parameters of molecules in parallel guides downstream modifications harmonized with both the target location and disease.

Features

  • Comprehensive suite of custom assays including:
    • protein-peptide binding,
    • multi-channel competition,
    • enzyme substrate characterization and inhibition, and
    • proteolytic stability
  • Each assay enables efficient characterization of every library member
  • Each assay can be customized to enable tailored characterization of target of interest

Additional Information & Resources

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Informatics

Our advanced and proprietary analytical pipeline, integrating bioinformatics, chemoinformatics, and machine learning, is engineered from the ground up to transform massive empirical data sets into actionable insights.  This purpose-built informatics platform is applied to both de novo library design and subsequent characterization of the resulting empirical data.  This process informs creation of the next bespoke library, and fuels a rapid, highly iterative approach to engineering peptides optimized for multiple characteristics in parallel.

Features

  • Data analytics for robust evaluation of structure activity relationships (SAR) independent of crystallography
  • Analysis of extensive empirical data informs multi-parameter optimization of pharmaceutical properties
  • Purpose built informatics pipeline, leveraging a variety of chemical descriptors, aids navigation of vast chemical space and informs design of subsequent libraries

Additional Information & Resources

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Featured Presentations

Our veteran team of scientists and engineers are invited to regularly participate in conferences around the world.  A selection of recorded presentations and related media is featured here.  Access additional content from our growing resource library by following the link below.

Introduction
History & Technology
Discovery Workflow
Introduction
History & Technology